Frontline 0.25% Spray

Frontline 0.25% Spray contains the active ingredient Fipronil to treat and prevent flea, tick and biting infestations in dogs and cats.
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Frontline 0.25% Spray

Frontline 0.25% Spray contains the active ingredient Fipronil to treat and prevent flea (Ctenocephalides species) and tick (Ixodes species) infestations in cats and dogs and to 
control infestations with Trichodectes canis biting lice on dogs, and Felicola subrostratus biting lice on cats. It can be used as part of a treatment strategy for Flea Allergy Dermatitis in cats and dogs where this has been previously diagnosed by a veterinary surgeon.

Frontline 0.25% Spray can be used safely on puppies and kittens from 2 days of age. It is active for up to 3 months against fleas in dogs and 2 months in cats, depending on the environmental challenge. It is effective for up to one month against ticks in both dogs and cats, again depending on the level of environmental challenge. The minimum interval between treatments is 4 weeks. 

Frontline 0.25% Spray is available in 250ml and 500ml bottles that each deliver 1.5ml per spray.  The 250ml pack contains approximately 4 treatments for a short haired medium sized dog (20kg). The 500ml pack contains approximately 8 treatments for a short haired medium sized dog (20kg).


Animals should be weighed accurately prior to treatment.

For optimum efficacy, it is not recommended to bathe or shampoo animals in the two days prior to or following treatment with the product. Bathing or shampooing up to four times in two months has been shown to have no significant effect on the residual efficacy of the product. Monthly treatment is recommended when more frequent shampooing is carried out.

In order to dampen the coat down to the skin, depending on the length of hair, apply 3 to 6ml per kg bodyweight, (7.5 to 15mg of active ingredient per kg bodyweight) i.e. 6 to 12 pump applications per kg bodyweight of the 100ml presentation, or 2 to 4 pump applications of the 250ml and 500ml presentations.
  • Adjust the pump nozzle to spray setting.
  • Spray the entire body of the animal, from a distance of approximately 10-20cm.
  • Apply against the lay of the hair and make sure that the entire coat of the animal is dampened. Ruffle the coat, especially in long haired animals, so that the product penetrates down to the skin.
  • For treatment of the head region, and when treating young or nervous pets, application may be carried out by spraying onto a gloved hand and rubbing the product into the coat. Allow to dry naturally. Do not towel dry.


  • Active Ingredient: Fipronil 0.25 % w/v, Hydro-alcoholic vehicle q.s. 100.00 % w/v.
  • Other Ingredients: Copolymer of vinylpyrrolidin-2-one and vinyl acetate, Isopropyl Alcohol, Water Purified.


  • Do not use simultaneously with other flea products which are applied directly onto the animal.
  • Do not use on sick (systemic diseases, fever…) or convalescent animals.
  • Do not use in rabbits, as adverse reactions and even death could occur.
  • Do not exceed the recommended dosage.
  • Avoid contact with the animal's eyes.
  • Do not spray directly onto areas of broken skin.
  • Allow treated animals to dry in a well ventilated room.
  • Do not confine animals in an enclosed space or pet carrier until the coat is totally dry.
  • In the absence of specific tolerance and efficacy data, the product is not recommended for the treatment of species other than cats and dogs.
  • When treating infestations of parasites, all in-contact animals should be treated with an appropriate product at the same time.
  • It is important to make sure that animals do not lick each other following treatment.
  • There may be an attachment of single ticks. For this reason a transmission of infectious diseases cannot be completely excluded if conditions are unfavourable.
  • Keep treated animals away from fires or other sources of heat, and surfaces likely to be affected by the alcohol spray, for at least 30 minutes following spraying and until the fur is totally dry. Do not spray on a naked flame or any incandescent material.
  • For external use only.
  • This product can cause mucous membrane and eye irritation. Therefore, contact between the product and the mouth and eyes should be avoided. Following accidental ocular exposure the eye(s) should be rinsed carefully with clean water. 
  • People with a known hypersensitivity to fipronil or any of the other ingredients should avoid contact with the product. Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water. 
  • Treated animals should not be handled until the fur is dry, and children should not be allowed to play with treated animals until the fur is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.
  • Spray animals in the open air or a well ventilated room.
  • Do not breathe spray. Do not smoke, drink or eat during application.
  • Wear PVC or nitrile gloves during treatment of animals. It is recommended to wear a waterproof apron for the protection of clothing.
  • If clothing becomes heavily wetted with the product, it should be removed and washed before re-use.
  • Dispose of gloves after use and then wash hands with soap and water.
  • Wash splashes from skin with soap and water immediately. If irritation occurs, seek medical advice. People with known sensitivity or asthma may be particularly sensitive to the product. Do not use product if you have previously experienced a reaction to it.
  • Treatment of multiple animals: Good ventilation is particularly important where several animals are to be treated. Treat multiple animals outside, or reduce the build up of vapour by removing the animals from the treatment room while the alcohol is evaporating and ensure that the treatment room is well ventilated between individual treatments. In addition, ensure that the drying room is well ventilated and avoid housing several recently treated animals within the same air space.
  • Fipronil may adversely affect aquatic organisms. Dogs should not be allowed to swim in water courses for 2 days after application.

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